Specifically, we are interested in understanding:

• how climate variability and other extrinsic factors, such as vaccination and vector reduction, influence disease dynamics;

• how immune escape affects disease dynamics, and how we can detect the occurrence of immune escape;

• how genotype-phenotype relationships and molecular constraints influence the evolutionary and ecological dynamics of RNA viruses, such as influenza, dengue, and HIV;

• how space influences the ecological and evolutionary dynamics of infectious diseases.

We develop mathematical models that can be confronted with empirical data. Because the lab's main focus is on rapidly evolving RNA viruses, we work with both epidemiological time series data and viral sequence data. If interested, please see the Publications page for more.