2010

Franke, J.D., R.A. Montague, D.P. Kiehart. (2010). Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. Dev Biol 345(2):117-32.

2009

Layton, A.T., Y. Toyama, G.Q. Yang, G.S. Edwards, D.P. Kiehart, S. Venakides. (2009).Drosophila morphogenesis: tissue force laws and the modeling of dorsal closure. HFSP J 3(6): 441-60.

2008

Toyama, Y., X. G. Peralta, A.R. Wells, D. P. Kiehart and Edwards, G. S. (2008). Apoptotic force and tissue dynamics during Drosophila embryogenesis. Science 321(5896): 1683-6.

 

Todi, S. V., E. Sivan-Loukianova, J. S. Jacobs and D. P. Kiehart, D. F. Eberl. (2008). "Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development." PLoS One 3(5): e2115.

 

Rodriguez-Diaz, A., Y. Toyama, D. L. Abravanel, J. M. Wiemann, A. R. Wells, U. S. Tulu, G. S. Edwards and D.P. Kiehart. (2008). "Actomyosin purse strings: renewable resources that make morphogenesis robust and resilient." HFSP J 2(4): 220-37.

 

Peralta, X. G., Y. Toyama, D. P. Kiehart and G. S. Edwards. (2008). "Emergent properties during dorsal closure in Drosophila morphogenesis." Phys Biol 5(1): 15004.

 

2007

Peralta, X. G., Y. Toyama, M. S. Hutson, R. Montague, S. Venakides, D.P. Kiehart and G. S. Edwards. (2007). "Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development." Biophys J 92(7): 2583-96.

 

Franke, J. D., R. A. Montague, W. L. Rickroll and D.P. Kiehart. (2007). "An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character." Hum Mol Genet 16(24): 3160-73.

 

2006

Yang, Y., M. Kovacs, T. Sakamoto, F. Zhang, D. P. Kiehart and J. R. Sellers. (2006). "Dimerized Drosophila myosin VIIa: a processive motor." Proc Natl Acad Sci U S A 103(15): 5746-51.

Homsy, J. G., H. Jasper, X. G. Peralta, H. Wu, D. P. Kiehart and D. Bohmann. (2006). "JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis." Dev Dyn 235(2): 427-34.

Franke, J. D., A. L. Boury, N. J. Gerald and D. P. Kiehart. (2006). "Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster." Cell Motil Cytoskeleton 63(10): 604

2005

Todi, S. V., J. D. Franke, D. P. Kiehart and D. F. Eberl. (2005). "Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila." Curr Biol 15(9): 862-8.

Franke, J. D., R. A. Montague and D. P. Kiehart. (2005). "Nonmuscle myosin II generates forces that transmit tension and drive contraction in multiple tissues during dorsal closure." Curr Biol 15(24): 2208-21

Franke, J. D., F. Dong, W.L. Rickroll, M. J. Kelley and D. P. Kiehart. (2005). "Rod mutations associated with MYH9-related disorders disrupt nonmuscle myosin-IIA assembly." Blood 105(1): 161-9.

 

2004

Kiehart, D. P., J. D. Franke, M. K. Chee, R. A. Montague, T.L. Chen, J. Roote and  M. Ashburner (2004). "Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA." Genetics 168(3): 1337-52.

 

Dorman, J. B., K. E. James, S.E. Freaser, D. P. Kiehart and  C. A. Berg. (2004). "bullwinkle is required for epithelial morphogenesis during Drosophila morphogenesis." Dev Biol 267(2): 320-41.

2003

Kiehart, D. P. (2003). "Myosins motor Miranda." Mol Cell 12(6): 1346-7.
           

Hutson, M. S., Y. Tokutake, M. S. Chang, J. W. Bloor, S. Venakides, D. P. Kiehart and G. S. Edwards. (2003). "Forces for morphogenesis investigated with laser microsurgery and quantitative modeling." Science 300(5616): 145-9.

 

Edwards, G. S., R. H. Austin, F. E. Carroll, M. L. Copeland, M. E. Couprie, W. E. Gabella, R. F. Haglund, B. A. Hooper, M. S. Hutson, E. D. Jansen, K. M. Joos, D. P. Kiehart, I. Lindau,  J. Miao, H. S. Pratisto, J. H. Shen, Y.Tokutake, A. F. G. van der Meer and A. Xie. (2003). "Free-electron-laser-based biophysical and biomedical instrumentation." Review of Scientific Instruments 74(7): 3207-3245.

 

Bayer, C. A., S. R. Halsell, J. W. Fristrom, D. P. Kiehart and L von Kalm.(2003). "Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis." Genetics 165(3): 1417-32.

 

Earlier Publications

 

2002

Ohashi, T., D. P. Kiehart and H. P. Erickson. (2002). "Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants." J Cell Sci 115(Pt 6): 1221-9.

 

Kiehart, D. P. and J. D. Franke (2002). "Actin dynamics: the arp2/3 complex branches out." Curr Biol 12(16): R557-9.

 

Dutta, D., J. W. Bloor, M. Ruiz-Gomez, K. VijayRaghavan and D. P. Kiehart. (2002). "Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin." Genesis 34(1-2): 146-51.

 

Bloor, J. W. and D. P. Kiehart (2002). "Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis." Development 129(13): 3173-83.

 

2001

Su, Z. and D. P. Kiehart (2001). "Protein kinase C phosphorylates nonmuscle myosin-II heavy chain from Drosophila but regulation of myosin function by this enzyme is not required for viability in flies." Biochemistry 40(12): 3606-14.

 

Crawford, J. M., Z. Su, O. Varlamova, A. R. Bresnick and D. P. Kiehart. (2001). "Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization." Eur J Cell Biol 80(3): 240-4.

 

Bloor, J. W. and D. P. Kiehart (2001). "zipper nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation." Dev Biol 239(2): 215-28.

 

2000

Kiehart, D. P., C. G. Galbraith, K. A Edwards, W.L. Rickroll and R. A. Montague. (2000). "Multiple forces contribute to cell sheet morphogenesis for dorsal closure in Drosophila." J Cell Biol 149(2): 471-90.

 

Halsell, S. R., B. I. Chu and D. P. Kiehart. (2000). "Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis." Genetics 155(3): 1253-65.

 

Halsell, S. R., B. I. Chu and D. P. Kiehart. (2000). "Genetic analysis demonstrates a direct link between Rho signaling and nonmuscle myosin function during Drosophila morphogenesis." Genetics 156(1): 469.

 

Champagne, M. B., K. A. Edwards, H. P. Erickson and D. P. Kiehart. (2000). "Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family." J Mol Biol 300(4): 759-77.

 

1999

Ohashi, T., D. P. Kiehart and H. P. Erickson. (1999). "Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein." Proc Natl Acad Sci U S A 96(5): 2153-8.

 

Kiehart, D. P. (1999). "Wound healing: The power of the purse string." Curr Biol 9(16): {Thomas, 1998 #51}R602-5.

 

Crawford, J. M. and D. P. Kiehart (1999). "Biology in pictures: From one cell to many." Curr Biol 9(11): R389.

 

1998

Thomas, G. H., D. C. Zarnescu, A. E. Juedes, M. A. Bales, A. Londergan, C. C. Korte and D. P. Kiehart. (1998). "Drosophila beta heavy-spectrin is essential for development and contributes to specific cell fates in the eye." Development 125(11): 2125-34.

 

Halsell, S. R. and D. P. Kiehart (1998). "Second-site noncomplementation identifies genomic regions required for Drosophila nonmuscle myosin function during morphogenesis." Genetics 148(4): 1845-63.

 

Crawford, J. M., N. Harden, T. Leung, L. Lim and D. P. Kiehart. (1998). "Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function." Dev Biol 204(1): 151-64.

 

Aitken, P. G., A. J. Borgdorff, A. J. Juta, D. P. Kiehart, G. G. Somjen and W. J. Wadman. (1998). "Volume changes induced by osmotic stress in freshly isolated rat hippocampal neurons." Pflugers Arch 436(6): 991-8.

 

1997

Thomas, G. H., E. C. Newbern, C. C. Korte, M. A. Bales, S. V. Muse, A. G. Clark and D. P. Kiehart. (1997). "Intragenic duplication and divergence in the spectrin superfamily of proteins." Mol Biol Evol 14(12): 1285-95.

 

Edwards, K. A., M. Demsky, R. A. Montague, N. Weymouth and D. P, Kiehart. (1997). "GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila." Dev Biol 191(1): 103-17.

 

1996

Pederson, J. D., D. P. Kiehart and J. W. Mahaffey. (1996). "The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype." Dev Biol 180(1): 131-42.

 

Mansfield, S. G., D. Y. al-Shirawi, A. S. Ketchum, E. C. Newbern and D. P. Kiehart. (1996). "Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain." J Mol Biol 255(1): 98-109.

 

Edwards, K. A. and D. P. Kiehart (1996). "Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis." Development 122(5): 1499-511.

 

Cooper, J. A. and D. P. Kiehart (1996). "Septins may form a ubiquitous family of cytoskeletal filaments." J Cell Biol 134(6): 1345-8.

           
1995

Miller, K. G. and D. P. Kiehart (1995). "Fly division." J Cell Biol 131(1): 1-5.

 

Edwards, K. A., X. J. Chang and D. P. Kiehart. (1995). "Essential light chain of Drosophila nonmuscle myosin II." J Muscle Res Cell Motil 16(5): 491-8.

           
1994

Thomas, G. H. and D. P. Kiehart (1994). "Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis." Development 120(7): 2039-50.

 

Kiehart, D. P., R. A. Montague, W. L. Rickroll, D. Foard and G. H. Thomas. (1994). "High-resolution microscopic methods for the analysis of cellular movements in Drosophila embryos." Methods Cell Biol 44: 507-32.
           

Edwards, K. A., R. A. Montague, S. Shepard, B. A. Edgar, R. L. Erikson and D. P. Kiehart. (1994). "Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast." Proc Natl Acad Sci U S A 91(10): 4589-93.

 

1993

Young, P. E., A. M. Richman, A. S. Ketchum and D. P. Kiehart. (1993). "Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function." Genes Dev 7(1): 29-41.

 

1991

Young, P. E., T. C. Pesacreta and D. P. Kiehart. (1991). "Dynamic changes in the distribution of cytoplasmic myosin during Drosophila embryogenesis." Development 111(1): 1-14.

 

Kiehart, D. P. (1991). "Contractile and Cytoskeletal Proteins in Drosophila Embryogenesis." Current Topics in Membranes 38: 79-97.

 

Karess, R. E., X. J. Chang, K. A. Edwards, S. Kulkarni, I. Aguilera and D. P. Kiehart. (1991). "The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila." Cell 65(7): 1177-89.

 

1990
     
Rimm, D. L., D. A. Kaiser, D. Bhandari, P. Maupin, D. P. Kiehart and T. D. Pollard. (1990). "Identification of functional regions on the tail of Acanthamoeba myosin-II using recombinant fusion proteins. I. High resolution epitope mapping and characterization of monoclonal antibody binding sites." J Cell Biol 111(6 Pt 1): 2405-16.

 

Kiehart, D. P., A. Ketchum, P. Young, D. Lutz, M. R Alfenito, X. J. Chang, M. Awobuluyi, T. C. Pesacreta, S. Inoue and C. T.

Stewart. (1990). "Contractile proteins in Drosophila development." Ann N Y Acad Sci 582: 233-51.

 

Kiehart, D. P. (1990). "Molecular genetic dissection of myosin heavy chain function." Cell 60(3): 347-50.

 

Kiehart, D. P. (1990). "The actin membrane skeleton in Drosophila development." Semin Cell Biol 1(5): 325-39.

 

Ketchum, A. S., C. T. Stewart, M. Stewart and D. P. Kiehart. (1990). "Complete sequence of the Drosophila nonmuscle myosin heavy-chain transcript: conserved sequences in the myosin tail and differential splicing in the 5' untranslated sequence." Proc Natl Acad Sci U S A 87(16): 6316-20.

 

Dubreuil, R. R., T. J. Byers, C. T. Stewart and D. P. Kiehart. (1990). "A beta-spectrin isoform from Drosophila (beta H) is similar in size to vertebrate dystrophin." J Cell Biol 111(5 Pt 1): 1849-58.

 

1989

Pesacreta, T. C., T. J. Byers, R. Dubreuil, D. P. Kiehart and D. Branton. (1989). "Drosophila spectrin: the membrane skeleton during embryogenesis." J Cell Biol 108(5): 1697-709.

 

Kiehart, D. P., M. S. Lutz, D. Chan, A. S. Ketchum, R. A. Laymon, B. Nguyen and L. S. Goldstein. (1989). "Identification of the gene for fly non-muscle myosin heavy chain: Drosophila myosin heavy chains are encoded by a gene family." EMBO J 8(3): 913-22.

 

1987

Dubreuil, R., T. J. Byers, D. Branton, L. S. Goldstein and D. P. Kiehart. (1987). "Drosophilia spectrin. I. Characterization of the purified protein." J Cell Biol 105(5): 2095-102.

 

Byers, T. J., R. Dubreuil, D. Branton, D. P. Kiehart and L. S. Goldstein. (1987). "Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins." J Cell Biol 105(5): 2103-10.

 

1986

Kiehart, D. P., D. A. Kaiser and T. D. Pollard. (1986). "Antibody inhibitors of nonmuscle myosin function and assembly." Methods Enzymol 134: 423-53.
           

Kiehart, D. P. and R. Feghali (1986). "Cytoplasmic myosin from Drosophila melanogaster." J Cell Biol 103(4): 1517-25.

 

Hagen, S. J., D. P. Kiehart, D. A. Kaiser and T. D. Pollard. (1986). "Characterization of monoclonal antibodies to Acanthamoeba myosin-I that cross-react with both myosin-II and low molecular mass nuclear proteins." J Cell Biol 103(6 Pt 1): 2121-8.

 

1985

Wong, A. J., D. P. Kiehart and T. D. Pollard. (1985). "Myosin from human erythrocytes." J Biol Chem 260(1): 46-9.

 

1984

Kiehart, D. P. and T. D. Pollard (1984). "Stimulation of Acanthamoeba actomyosin atpase activity by myosin-II polymerization." Nature 308(5962): 864-866.
           

Kiehart, D. P. and T. D. Pollard (1984). "Inhibition of Acanthamoeba actomyosin-II ATPase activity and mechanochemical function by specific monoclonal antibodies." J Cell Biol 99(3): 1024-33

 

Kiehart, D. P., D. A. Kaiser and T. D. Pollard. (1984). "Monoclonal antibodies demonstrate limited structural homology between myosin isozymes from Acanthamoeba." J Cell Biol 99(3): 1002-14.

 

Kiehart, D. P., D. A. Kaiser and T. D. Pollard. (1984). "Direct localization of monoclonal antibody-binding sites on Acanthamoeba myosin-II and inhibition of filament formation by antibodies that bind to specific sites on the myosin-II tail." J Cell Biol 99(3): 1015-23.

 

Eisen, A., D. P. Kiehart, S. J. Wieland and  G. T. Reynolds. (1984). "Temporal sequence and spatial distribution of early events of fertilization in single sea urchin eggs." J Cell Biol 99(5): 1647-54.

 

1982

Pollard, T. D., U. Aebi, J. A. Cooper, W. E. Fowler, D. P. Kiehart, P. R. Smith and P. C. Tseng. (1982). "Actin and myosin function in Acanthamoeba." Philos Trans R Soc Lond B Biol Sci 299(1095): 237-45.

 

Kiehart, D. P., I. Mabuchi and S. Inoue. (1982). "Evidence that myosin does not contribute to force production in chromosome movement." J Cell Biol 94(1): 165-78.

 

Kiehart, D. P. (1982). "Microinjection of echinoderm eggs: apparatus and procedures." Methods Cell Biol 25 Pt B: 13-31.

 

1981

Kiehart, D. P. (1981). "Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system." J Cell Biol 88(3): 604-17.

 

1978

Tilney, L. G., D. P. Kiehart, C. Sardet and M. Tilney. (1978). "Polymerization of actin. IV. Role of Ca++ and H+ in the assembly of actin and in membrane fusion in the acrosomal reaction of echinoderm sperm." J Cell Biol 77(2): 536-50.

 

1974

Inoue, S., G. G. Borisy and D. P. Kiehart. (1974). "Growth and liability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin." J Cell Biol 62(1): 175-84.